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1

Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease

Ghazi Hussein, Hirotsugu Miyashiro, Norio Nakamura, Masao Hattori, Takuya Kawahata, Toru Otake, Nobuko Kakiuchi, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

1999

Language:

english

File:

PDF, 74 KB

english, 1999

2

Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum

Sahar El-Mekkawy, Meselhy R. Meselhy, Norio Nakamura, Yasuhiro Tezuka, Masao Hattori, Nobuko Kakiuchi, Kunitada Shimotohno, Takuya Kawahata, Toru Otake

Journal:

Year:

1998

Language:

english

File:

PDF, 253 KB

english, 1998

3

Antioxidant activity of Magnolol, honokiol, and related phenolic compounds

Masahiro Ogata, Midori Hoshi, Kumiko Shimotohno, Shiro Urano, Toyoshige Endo

Journal:

Journal of the American Oil Chemists' Society

Year:

1997

Language:

english

File:

PDF, 507 KB

english, 1997

4

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues

Murakami, Y, Yasuda, T, Saigo, K, Urashima, T, Toyoda, H, Okanoue, T, Shimotohno, K

Journal:

Year:

2005

Language:

english

File:

PDF, 379 KB

english, 2005

5

Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication

Hishiki, Takayuki, Han, Qi’En, Arimoto, Kei-ichiro, Shimotohno, Kunitada, Igarashi, Tatsuhiko, Vasudevan, Subhash G., Suzuki, Youichi, Yamamoto, Naoki

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 805 KB

english, 2014

6

Importance of 5′-Terminal Blocking Structure to Stabilize mRNA in Eukaryotic Protein Synthesis

Kunitada Shimotohno, Yaeko Kodama, Junji Hashimoto and Kin-Ichiro Miura

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 1.32 MB

english, 1977

7

Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways

Kuo, Yi-Chen, Chen, I-Yin, Chang, Shin C., Wu, Shun-Chi, Hung, Tzu-Min, Lee, Po-Huang, Shimotohno, Kunitada, Chang, Ming-Fu

Journal:

Liver International

Year:

2014

Language:

english

File:

PDF, 643 KB

english, 2014

8

Cooperative Orthogonal Macromolecular Assemblies with Broad Spectrum Antiviral Activity, High Selectivity, and Resistance Mitigation

Ichiyama, Koji, Yang, Chuan, Chandrasekaran, Lakshmi, Liu, Shaoqiong, Rong, Lijun, Zhao, Yue, Gao, Shujun, Lee, Ashlynn, Ohba, Kenji, Suzuki, Youichi, Yoshinaka, Yoshiyuki, Shimotohno, Kunitada, Miyak

Journal:

Year:

2016

Language:

english

File:

PDF, 3.72 MB

english, 2016

9

Hepatitis C virus structural proteins induce liver cell injury in transgenic mice

Honda, Arata, Arai, Yutaka, Hirota, Norio, Sato, Takako, Ikegaki, Junichi, Koizumi, Tamio, Hatano, Masahiko, Kohara, Michinori, Moriyama, Takashi, Imawari, Michio, Shimotohno, Kunitada, Tokuhisa, Take

Journal:

Journal of Medical Virology

Year:

1999

Language:

english

File:

PDF, 2.30 MB

english, 1999

10

Comparison of hypervariable regions (HVR1 and HVR2) in positive- and negative-stranded hepatitis C virus RNA in cancerous and non-cancerous liver tissue, peripheral blood mononuclear cells and serum from a patient with hepatocellular carcinoma

Satoru Saito, Nobuyuki Kato, Makoto Hijikata, Toshiaki Gunji, Masayuki Itabashi, Masaaki Kondo, Katsuaki Tanaka, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 504 KB

english, 1996

11

A human immunodeficiency virus protease inhibitory substance from Swietenia mahagoni

Ines Tomoco Matsuse, Takeshi Nakabayashi, Yasmina Aura Lim, Ghazi M. E. Hussein, Hirotsugu Miyashiro, Nobuko Kakiuchi, Masao Hattori, Supriyatna Stardjo, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

1997

Language:

english

File:

PDF, 83 KB

english, 1997

12

Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus

Yasmina Aura Lim, Shiho Kojima, Norio Nakamura, Hirotsugu Miyashiro, Hirotoshi Fushimi, Katsuko Komatsu, Masao Hattori, Kunitada Shimotohno, Mahabir P. Gupta, Mireya Correa

Journal:

Phytotherapy Research

Year:

1997

Language:

english

File:

PDF, 94 KB

english, 1997

13

Inhibitory effects of ursolic acid derivatives from Cynomorium songaricum, and related triterpenes on human immunodeficiency viral protease

Chaomei Ma, Norio Nakamura, Hirotsugu Miyashiro, Masao Hattori, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

1998

Language:

english

File:

PDF, 104 KB

english, 1998

14

Screening of Korean plants against human immunodeficiency virus type 1 protease

Byung Sun Min, Ki Hwan Bae, Young Ho Kim, Hirotsugu Miyashiro, Masao Hattori, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

1999

Language:

english

File:

PDF, 45 KB

english, 1999

15

Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease

Ghazi Hussein, Hirotsugu Miyashiro, Norio Nakamura, Masao Hattori, Nobuko Kakiuchi, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

2000

Language:

english

File:

PDF, 86 KB

english, 2000

16

ChemInform Abstract: Microbial and Chemical Conversion of Antibiotic K-41. Part 1. Isolation and Identification of Conversion Product.

M. HOSHI, K. W. SHIMOTOHNO, T. ENDO, K. FURIHATA, H. SETO

Journal:

Year:

1997

File:

PDF, 28 KB

1997

17

ChemInform Abstract: A New Enzyme, Edeine B1 Amidinohydrolase, from Bacillus brevis TT02-8. Purification and Determination of the N-Terminal Amino Acid Sequence.

Kumiko W. Shimotohno, Junko Iida, Toyoshige Endo

Journal:

Year:

1999

File:

PDF, 30 KB

1999

18

ChemInform Abstract: Studies on the Biosynthesis of Bialaphos (SF-1293). Part 18. 2-Phosphinomethylmalic Acid Synthase: A Descendant of (R)-Citrate Synthase?

Tomomi Hidaka, Kumiko W. Shimotohno, Takehiko Morishita, Haruo Seto

Journal:

Year:

2000

File:

PDF, 25 KB

2000

19

ChemInform Abstract: Two New Diterpenoids from Plectranthus nummularius Briq.

Yuji Narukawa, Noriko Shimizu, Kumiko Shimotohno, Tadahiro Takeda

Journal:

Year:

2002

File:

PDF, 26 KB

2002

20

Human Immunodeficiency Virus-Reverse Transcriptase Inhibition and Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibition Activities of Fullerene Derivatives.

Tadahiko Mashino, Kumiko Shimotohno, Noriko Ikegami, Dai Nishikawa, Kensuke Okuda, Kyoko Takahashi, Shigeo Nakamura, Masataka Mochizuki

Journal:

Year:

2005

File:

PDF, 8 KB

2005

21

Gerbils of a seizure-sensitive strain have a mitochondrial inner membrane protein with different isoelectric points from those of a seizure-resistant strain

Akira Omori, Sachiyo Ichinose, Satoko Kitajima, Kumiko W. Shimotohno, Yoshiya L. Murashima, Kunitada Shimotohno, Akiko Seto-Ohshima

Journal:

ELECTROPHORESIS

Year:

2002

Language:

english

File:

PDF, 293 KB

english, 2002

22

The development of anti-hepatitis C virus agents

Kunitada Shimotohno

Journal:

Year:

1995

Language:

english

File:

PDF, 263 KB

english, 1995

23

Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus

Hussein Hassan Aly, Yue Qi, Kimie Atsuzawa, Nobuteru Usuda, Yasutsugu Takada, Masashi Mizokami, Kunitada Shimotohno, Makoto Hijikata

Journal:

Year:

2009

Language:

english

File:

PDF, 822 KB

english, 2009

24

Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen

Hiroyuki Marusawa, Shinji Uemoto, Makoto Hijikata, Yoshihide Ueda, Koichi Tanaka, Kunitada Shimotohno, Tsutomu Chiba

Journal:

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

25

Wnt/β-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts

Yoshihide Ueda, Makoto Hijikata, Shinji Takagi, Ritsuko Takada, Shinji Takada, Tsutomu Chiba, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 474 KB

english, 2002

26

Immortalization of peripheral blood lymphocytes of cats by human T-cell leukemia virus

H. Hoshino, H. Tanaka, K. Shimotohno, M. Miwa, M. Nagai, M. Shimoyama, T. Sugimura

Journal:

International Journal of Cancer

Year:

1984

Language:

english

File:

PDF, 566 KB

english, 1984

27

Methylation pattern of human T-cell leukemia virus in vivo and in vitro: pX and LTR regions are hypomethylated in vivo

Toshio Kitamura, Masako Takano, Hiroo Hoshino, Kunitada Shimotohno, Masanori Shimoyama, Masanao Miwa, Fumimaro Takaku, Takashi Sugimura

Journal:

International Journal of Cancer

Year:

1985

Language:

english

File:

PDF, 1.02 MB

english, 1985

28

DNA blotting analysis of human retroviruses in cerebrospinal fluid of spastic paraparesis patients: The viruses are identical to human T-cell leukemia virus type-1 (HTLV-1)

Jun Imamura, Atsumi Tsujimoto, Yoshihiro Ohta, Shozo Hirose, Kunitada Shimotohno, Masanao Miwa, Isao Miyoshi

Journal:

International Journal of Cancer

Year:

1988

Language:

english

File:

PDF, 741 KB

english, 1988

29

Generation and characterization of monoclonal antibodies against multiple epitopes on the C-terminal half of envelope gp46 of human T-cell leukemia virus type-I (HTLV-I)

Yuetsu Tanaka, Masazumi Yasumoto, Hiroshi Nyunoya, Tsutomu Ogura, Masayoshi Kikuchi, Kunitada Shimotohno, Hiroshi Shiraki, Naotaka Kuroda, Hisatoshi Shida, Hideki Tozawa

Journal:

International Journal of Cancer

Year:

1990

Language:

english

File:

PDF, 1000 KB

english, 1990

30

Sequence variations in ltr and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia

Tomohiro Kinoshita, Atsumi Tsujimoto, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 500 KB

english, 1991

31

Production of a recombinant human T-cell leukemia virus type-I trans-activator (tax1) antigen and its utilization for generation of monoclonal antibodies against various epitopes on the tax1 antigen

Yuetsu Tanaka, Atsushi Yoshida, Hideki Tozawa, Hisatoshi Shida, Hiroshi Nyunoya, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 967 KB

english, 1991

32

Infection of rats with HTLV-1: A small-animal model for HTLV-1 carriers

T. Suga, T. Kameyama, T. Kinoshita, K. Shimotohno, M. Matsumura, H. Tanaka, S. Kushida, Y. Ami, M. Uchida, K. Uchida, M. Miwa

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 696 KB

english, 1991

33

Correlation between the serum level of hepatitis C virus RNA and disease activities in acute and chronic hepatitis C

Toshiaki Gunji, Nobuyuki Kato, Shigehisa Mori, Yuko Ootsuyama, Makoto Hijikata, Michio Imawari, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 518 KB

english, 1992

34

Absence of HTLV-I infection among seronegative subjects in an endemic area of Japan

Tomohiro Kinoshita, Jun Imamura, Hirokazu Nagai, Kunitada Shimotohno, Mizuko Ito, Shin-Ichiro Ito, Shuichi Ikeda, Masazumi Nagatomo, Kazuo Tajima

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 605 KB

english, 1993

35

Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrier

Takahide Nakazawa, Nobuyuki Kato, Yuko Ootsuyama, Hitomi Sekiya, Takahiro Fujioka, Akitaka Shibuya, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 920 KB

english, 1994

36

Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1

Hitomi Sekiya, Nobuyuki Kato, Yuko Ootsuyama, Takahide Nakazawa, Katsumi Yamauchi, Kunitada Shimotohno

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 940 KB

english, 1994

37

HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element

Takayuki Ohshima, Risa Mukai, Norie Nakahara, Jun Matsumoto, Osamu Isono, Yusuke Kobayashi, Satoru Takahashi, Kunitada Shimotohno

Journal:

Journal of Cellular Biochemistry

Year:

2010

Language:

english

File:

PDF, 297 KB

english, 2010

38

Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment

Mitsuyasu Nakamura, Hidetsugu Saito, Masanori Ikeda, Shinichiro Tada, Naoki Kumagai, Nobuyuki Kato, Kunitada Shimotohno, Toshifumi Hibi

Journal:

Journal of Medical Virology

Year:

2008

Language:

english

File:

PDF, 237 KB

english, 2008

39

A Novel Method for Analysis of Viral Proteinase Activity Encoded by Hepatitis C Virus in Cultured Cells

Y. Hirowatari, M. Hijikata, K. Shimotohno

Journal:

Analytical Biochemistry

Year:

1995

File:

PDF, 682 KB

1995

40

An Enzyme-Linked Immunosorbent Assay for Detecting Proteolytic Activity of Hepatitis C Virus Proteinase

Norisue Takeshita, Nobuko Kakiuchi, Tsutomu Kanazawa, Yasumasa Komoda, Makoto Nishizawa, Tadato Tani, Kunitada Shimotohno

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 115 KB

english, 1997

41

5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents

Masahiro Ikejiri, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 272 KB

english, 2007

42

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Tadahiko Mashino, Kumiko Shimotohno, Noriko Ikegami, Dai Nishikawa, Kensuke Okuda, Kyoko Takahashi, Shigeo Nakamura, Masataka Mochizuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

43

Synthesis and evaluation of 5′-modified 2′-deoxyadenosine analogues as anti-hepatitis C virus agents

Masahiro Ikejiri, Takayuki Ohshima, Akemi Fukushima, Kunitada Shimotohno, Tokumi Maruyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 257 KB

english, 2008

44

Feasibility of D3He/ST fusion power reactor

Hidetoshi Shimotohno, Satoshi Nishio, Syunsuke Kondo

Journal:

Fusion Engineering and Design

Year:

2003

Language:

english

File:

PDF, 748 KB

english, 2003

45

Isolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease

Kotaro Fukuda, Daesety Vishnuvardhan, Satoru Sekiya, Joonsung Hwang, Nobuko Kakiuchi, Kazunari Taira, Kunitada Shimotohno, Penmetcha K. R. Kumar, Satoshi Nishikawa

Journal:

Year:

2000

Language:

english

File:

PDF, 935 KB

english, 2000

46

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C

Yoshiki Murakami, Masami Tanaka, Hidenori Toyoda, Katsuyuki Hayashi, Masahiko Kuroda, Atsushi Tajima, Kunitada Shimotohno

Journal:

BMC Medical Genomics

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

47

Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease

Ines Tomoco Kusumoto, Takeshi Nakabayashi, Hiroaki Kida, Hirotsugu Miyashiro, Masao Hattori, Tsuneo Namba, Kunitada Shimotohno

Journal:

Phytotherapy Research

Year:

1995

Language:

english

File:

PDF, 483 KB

english, 1995

48

Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy

Koichi Watashi, Kunitada Shimotohno

Journal:

Reviews in Medical Virology

Year:

2007

Language:

english

File:

PDF, 244 KB

english, 2007

49

Specific detection of positive and negative stranded hepatitis C viral RNA using chemical RNA modification

T. Gunji, N. Kato, M. Hijikata, K. Hayashi, S. Saitoh, K. Shimotohno

Journal:

Archives of Virology

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

50

Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector

Y. Hirowatari, M. Hijikata, Y. Tanji, H. Nyunoya, H. Mizushima, K. Kimura, T. Tanaka, N. Kato, K. Shimotohno

Journal:

Archives of Virology

Year:

1993

Language:

english

File:

PDF, 698 KB

english, 1993

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